2′-C-メチルアデノシン

化学名:2′-C-メチルアデノシン

CAS番号.15397-12-3

英語名:2'-C-Methyladenosine

CBNumberCB31177964

MFC11H15N5O4

MW281.27

MOL File15397-12-3.mol

别名

(2R,3R,4R,5R)-2-(6-アミノ-9H-プリン-9-イル)-5-(ヒドロキシメチル)-3-メチルオキソラン-3,4-ジオール

2′-C-メチルアデノシン

2′-メチルアデノシン

2′-C-メチルアデノシン物理性質

沸点	643.4±65.0 °C(Predicted)
比重(密度)	1.89
貯蔵温度	Store at -20°C
溶解性	DMF: 5 mg/mL; DMSO: 20 mg/mL; PBS (pH 7.2): 10 mg/mL
外見	A crystalline solid
酸解離定数(Pka)	13.18±0.70(Predicted)
色	White to off-white

2′-C-メチルアデノシン価格

製品番号	包装	価格	購入
富士フイルム和光純薬株式会社(wako) W01COBQB-2336	250mg	￥75000	購入
富士フイルム和光純薬株式会社(wako) W01COBQB-2336	1g	￥157500	購入
富士フイルム和光純薬株式会社(wako) W01FLC527548	250mg	￥256300	購入
富士フイルム和光純薬株式会社(wako) W01FLC527548	1g	￥512500	購入
富士フイルム和光純薬株式会社(wako) W01FLC527548	5g	￥1280600	購入

2′-C-メチルアデノシン化学特性,用途語,生産方法

説明
2′-C-Methyladenosine has been shown to inhibit HCV RNA replication in the absence of cytotoxicity. The corresponding triphosphates were shown to be potent, competitive inhibitors of NS5B-catalyzed reactions in vitro.
生物活性
2’-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM.{39652} It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 μM) and eradicates it when used at a concentration of 10 μM.
合成

Synthesis of yfl-2'-methyl-adenosine (CHCl); N6-tert-butanoyl-/?-2'-methyl-2',3',5'-tribenzoyl-adenosine (400 mg, 0.590 mmol) was added to a solution of MeOH saturated with ammonia, and stirred at room temperature. After 12 hours the solvent was removed and the obtained solid was purified by column chromatography in gradient starting with a mixture of CHCl3/MeOH 9:1 then 8:2. The pure product was obtained as a white solid (120 mg, 0.427 mmol, 72%). |?H (J6-DMSO): 8.47 (IH, s, H8-adenosine), 8.15 (IH, s, H2-adenosine), 7.30 (IH, s, NH26-adenosine), 5.95 (IH, s, Hl '-adenosine), 5.25-5.21 (3H, m, OH5' -adenosine, OH3'- adenosine, OH2' -adenosine), 4.12-4.05 (IH, d, H3 '-adenosine, J= 8.6 Hz), 3.91 (IH, m, H4'-adenosine), 3.84 (IH, m, H5' -adenosine), 3.70 (IH, m, H5' -adenosine), 0.77 (3H3 s, CH32'-adenosine); |?c (4-DMSO): 156.02 (1C, C6-adenosine), 152.53 (1C, C2-adenosine), 149.01 (1C, C4-adenosine), 138.68 (1C, C8-adenosine), 118.67 (1C, C5-adenosine), 90.78 (1C, Cl '-adenosine), 82.52 (1C, C4' -adenosine), 78.46 (1C, C2'-adenosine), 71.63 (1C, C3' -adenosine), 59.47 (1C, C5 '-adenosine), 19.83 (1C, CH3-2'-adenosine). Anal. CaIc. for C11H15N5O4: C 46.97%, H 5.38%, N 24.90%. Found: C 46.67%, H 5.22%, N 24.20%.

2′-C-メチルアデノシン上流と下流の製品情報

2′-C-メチルアデノシン生産企業

15397-12-3, 2′-C-メチルアデノシンキーワード

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2′-C-メチルアデノシン

2′-C-メチルアデノシン 価格

2′-C-メチルアデノシン 化学特性,用途語,生産方法

2′-C-メチルアデノシン 上流と下流の製品情報

2′-C-メチルアデノシン 生産企業

15397-12-3, 2′-C-メチルアデノシン キーワード

2′-C-メチルアデノシン価格

2′-C-メチルアデノシン化学特性,用途語,生産方法

2′-C-メチルアデノシン上流と下流の製品情報

2′-C-メチルアデノシン生産企業

15397-12-3, 2′-C-メチルアデノシンキーワード