(3β,5Z,7E)-24-メチル-9,10-セココレスタ-5,7,10(19)-トリエン-3-オール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H330：吸入すると生命に危険

  H372：長期にわたる、または反復暴露により臓器の障 害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P314：気分が悪い時は、医師の診断/手当てを受けること。

(3β,5Z,7E)-24-メチル-9,10-セココレスタ-5,7,10(19)-トリエン-3-オール 価格

(3β,5Z,7E)-24-メチル-9,10-セココレスタ-5,7,10(19)-トリエン-3-オール 化学特性,用途語,生産方法

• 定義

  本品は、ビタミンD2であり、次の化学式で表される。

• 化粧品の成分用途

  皮膚コンディショニング剤

• 解説

  ビタミン D4：22,23-dihydroergocalciferol．C28H46O(398.66)．小板状結晶．融点96～98 ℃．λmax 265 nm．[α]²¹_D＋85.7°(アセトン)．22-ジヒドロエルゴステロールの紫外線照射により生成する．

  ビタミンDの生理作用としては，小腸でCaの吸収を促進し，さらに二次的にリンの吸収を促進し，また骨からのCaの動員を促進する．ネズミの実験的くる病はビタミンD欠乏と同時にCa/P比の大きい場合に起こるが，この比が正常または小さいときには起こらない．ビタミンDの生理活性型は1,25-ジヒドロキシビタミン D3．ビタミンDの欠乏症はくる病，骨軟化症であるが，ビタミンDの過剰投与により高Ca血症，Caの異所沈着などの過剰症が起こる．

• 説明

  Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.

• 化学的特性

  Pale Yellow Oil

• 使用

  Vitamin D4 is the active analogue of Vitamin D.

• 生物学の機能

  Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.

• Source

  Vitamin D is a 9,10-secosteroid and 6 forms have been identified. The importance of vitamin D in bone (calcium homeostasis) is well established, and vitamin D has been the subject of increased attention in recent years for its role in muscle function, immunology, heart and cardiovascular disease, cancer, and insulin secretion. The vitamin D4 precursor 22,23-dihydroergosterol was present in all mushroom composites. The levels were not correlated with vitamin D4, but differed among species. Enoki mushrooms had a notably higher 22,23-dihydroergosterol content, with an average of 16.5 mg/100g compared to 4.49–8.89 mg/ 100 g in other types of mushrooms.

(3β,5Z,7E)-24-メチル-9,10-セココレスタ-5,7,10(19)-トリエン-3-オール 生産企業

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