(R)-2-(2-Chlorophenyl)pyrrolidine

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

(R)-2-(2-Chlorophenyl)pyrrolidine 価格

(R)-2-(2-Chlorophenyl)pyrrolidine 化学特性,用途語,生産方法

• 化学的特性

  Flashing point: 107.5 °C . Vapour pressure: 0.0176mmHg at 25°C. (R)-2-(2-Chlorophenyl)pyrrolidine is a chiral molecule whose optical isomer is (S)-2-(2-Chlorophenyl)pyrrolidine.

• 物理的性質

  A colorless crystal

• 使用

  (R)-2-(2-Chlorophenyl)pyrrolidine can be used as an intermediate for organic synthesis.

• 合成

  To a dry Schlenk flask under nitrogen is added 0.540 g of (R, R)- (+)-ETHYLENE-1, 2- bis (N5-4, 5,6, 7-TETRAHYDRO-L-INDENYL) titanium difluoride and 120 mL of dry THF. To this solution are added under nitrogen in the following order: 2- (2-chlorophenyl)-pyrroline (15 g), phenylsilane (15 g), pyrrolidine (0.48 mL), and MeOH (0.24 mL). The solution is stirred at RT for 48 h, then the mixture is diluted with 350 mL of diethylether and carefully added with vigorous stirring to 1200 mL of 1 M HCI. The aqueous layer is separated and extracted with three portions of diethyl ether (300 mL each). The aqueous layer is made basic with 3M NAOH and extracted with 5 portions of diethyl ether (200 mL each). The combined ether layers are dried over magnesium sulfate and concentrated in vacuo. The residue is purified by vacuum transfer to give (R)-2-(2-Chlorophenyl)pyrrolidine (15 g, 93%) as a colorless oil.

(R)-2-(2-Chlorophenyl)pyrrolidine 生産企業

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