パラアルデヒド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H226：引火性の液体および蒸気

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P233：容器を密閉しておくこと。

  P240：容器を接地すること/アースをとること。

  P241：防爆型の電気機器/換気装置/照明機器/．．．機器を使 用すること。

  P242：火花を発生させない工具を使用すること。

  P243：静電気放電に対する予防措置を講ずること。

パラアルデヒド 価格

パラアルデヒド 化学特性,用途語,生産方法

• 外観

  無色～わずかにうすい黄色, 澄明の液体

• 性質

  C6H12O3(132.16)．パラアセトアルデヒドともいう．アセトアルデヒドの環状三量体．アセトアルデヒドに濃硫酸または塩酸を作用させてつくる．パラアルデヒドは，芳香をもつ無色の液体．融点12.6 ℃，沸点124.5 ℃．d²⁰₄0.9943．n²⁰_D1.4049．各種有機溶剤，水に可溶．アセトアルデヒドより引火性および反応性に乏しい．塩基に対しては安定であるが，酸により分解してアセトアルデヒドとなる．森北出版「化学辞典（第2版）

• 溶解性

  エタノール及びアセトンに極めて溶けやすく、水に溶ける。

• 解説

  アセトアルデヒドCH3CHOの6員環状の三量体。パラアセトアルデヒドともよばれる。アセトアルデヒドを濃硫酸、塩酸などとともに加熱すると生成する（図）。

  三量体を生成する反応は可逆反応であるので、酸の作用によりアセトアルデヒドが再生される。特有のにおいをもつ無色の液体で、水にかなり溶け、エタノール（エチルアルコール）、エーテルなどの有機溶媒と任意の割合で混じり合う。有機合成原料、医薬、樹脂、ゴムなどの溶剤、ゴムの加硫促進剤などに用いられる。［廣田　穰　2015年3月19日］

• 用途

  溶剤、有機合成原料。

• 用途

  香水、香料、染料、プラスチック、合成ゴム、酢酸、そのほか種々の有機化合物の合成原料。

• 効能

  催眠鎮静薬

• 説明

  Paraldehyde was first synthesized in 1829 by Wildenbusch and introduced into clinical practice in the United Kingdom by the Italian physician Vincenzo Cervello in 1882. Paraldehyde, a polymer of acetaldehyde, is a clear colorless or slightly yellow transparent liquid with a strong aromatic as well as a disagreeable taste that at low temperatures, it solidifies into a crystalline mass. This agent decomposes with strong into toxic products that may be released into water, soil, or atmosphere.

• 化学的特性

  Paraldehyde is a colourless to yellowish clear liquid. Pleasant, sweet odor. Less dense than water. Vapors are heavier than air.

• 使用

  Paraldehyde is used as solvent for fats, oils, waxes, rubber and resins; as substitute for acetaldehyde; as intermediate for organic chemicals, dyestuffs, accelerators for vulcanizations, rubber oxidants, etc. Product Data Sheet

• 製造方法

  Prepared by the polymerization of acetaldehyde catalyzed by hydrochloric acid and sulfuric acid at medium to high temperatures.

• 定義

  ChEBI: Paraldehyde is a trioxane that is 1,3,5-trioxane substituted by methyl groups at positions 2, 4 and 6. It has a role as a sedative.

• 一般的な説明

  Paraldehyde is recognizable as the cyclictrimer of acetaldehyde. It is a liquid with a strong characteristicodor detectable in the expired air and an unpleasanttaste. These properties limit its use almost exclusively toan institutional setting (e.g., in the treatment of deliriumtremens). In the past, when containers were opened and airadmitted and then reclosed and allowed to stand, fatalitiesoccurred because of oxidation of paraldehyde to glacialacetic acid.

• 空気と水の反応

  Highly flammable. Slightly soluble in water. Decomposed by light and air, on prolonged storage, to acetaldehyde and acetic acid.

• 反応プロフィール

  Paraldehyde is an aldehyde. Paraldehyde is decomposed by light and air, on prolonged storage, to acetaldehyde and acetic acid. Incompatible with alkalis, hydrocyanic acid iodides and oxidizers.

• 健康ハザード

  INHALATION AND INGESTION: Irritation, headache, bronchitis, pulmonary edema. Irritating to digestive tract. Hypnotic and analgesic properties. Incoordination and drowsiness, followed by sleep. Larger doses-coma-weak pulse and shallow respiration, cyanosis-death from respiratory paralysis. EYES: irritation-can cause serious injury. SKIN: Dermatitis (skin inflammation).

• 安全性プロファイル

  A human poison by rectal route. Moderately toxic to humans by intramuscular route. Moderately toxic experimentally by inhalation, ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by rectal route: necrotic changes. A skin and severe eye irritant. Low doses produce hypnotic and analgesic effects. Larger doses depress the nervous system with loss of reflexes, coma, and respiratory depression leadmg to respiratory paralysis and death. Chronic effects include weight loss, muscular weakness, and mental fatigue. However, poisoning is rare. A hypnotic agent. Dangerous fire hazard when exposed to heat, flame, or oxidzers. Slight explosion hazard when exposed to heat or flame. Dangerous; keep away from heat and open flame. To fight fire, use alcohol foam, CO2, dry chemical. Potentially violent reaction with nitric acid. Incompatible with alkahes, hydrocyanic acid, iodides, oxidzers. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES

• 職業ばく露

  Paraldehyde is used primarily in medicine. It is used as a hypnotic agent, in delirium tremens; and in treatment of psychiatric states characterized by excitement when drugs must be given over a long period of time. It also is administered for intractable pain which does not respond to opiates and for basal and obstetrical anesthesia. It is effective against experimentally induced convulsions and has been used in emergency therapy of tetanus, eclampsia, status epilepticus; and poisoning by convulsant drugs. Since it is used primarily in medicine, the chance of accidental human exposure or environmental contamination is low. However, paraldehyde decomposes to acetaldehyde and acetic acid; these compounds have been found to be toxic. In this case, occupational exposure or environmental contamination is possible. Since paraldehyde is prepared from acetaldehyde by polymerization in the presence of an acid catalyst, there exists a potential for adverse effects, although none have been reported in the available literature. It is also used in the manufacture of organic compounds.

• 環境運命予測

  Paraldehyde is used in resin manufacture, as a preservative, and in other processes as a solvent. Paraldehyde may enter to the environment via industrial effluents or hospital wastes. Acetaldehyde and acetic acid are two products of degradation of paraldehyde. This compound and its degradation products may be released into water, soil, or atmosphere and then they may be removed from the atmosphere by precipitation.

• 輸送方法

  UN1264 Paraldehyde, Hazard Class: 3; Labels: 3-Flammable liquid.

• 純化方法

  Wash paraldehyde with water and fractionally distil it. Alternatively, it is purified by drying with anhydrous Na2SO4, then cooled to 5o, and the frozen material is separated by decantation. The solid is distilled (b 121-124o/atm), the distillate is collected, stored over anhydrous Na2SO4 for several days and re-distilled at atmospheric pressure before use [Le Fevre et al. J Chem Soc 290 1950]. The 2r,4c,6t-trimethyl-1,3,5-trioxane has m 14.5o, b 125o/760mm. [Beilstein 19 II 394, 19 III/IV 4715. 19/9 V 112.]

• 不和合性

  Vapor or liquid may form explosive mixture with air. Incompatible with strong oxidants, strong acids; alkalis, ammonia, amines, iodides, hydrocyanic acid. Violent reaction with liquid oxygen. Contact with acids form acetaldehyde. Attacks rubber and plastics.

• 廃棄物の処理

  Incineration in added solvent. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

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パラアルデヒド スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

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