フルベンダゾール

化学名:フルベンダゾール

英語名:Flubendazole

CBNumberCB2669630

MFC16H12FN3O3

MW313.28

别名

フルベルマール

フルベンダゾール

フルモキサール

フルベンダゾール物理性質

安全性情報

Rフレーズ	22
Sフレーズ	44
WGK Germany	2
RTECS 番号	DD6497500
HSコード	29339900
毒性	LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont)

危険有害性情報のコード(GHS)

外観
白色～わずかにうすい黄色, 粉末
溶解性
ジメチルスルホキシドに溶け、水にほとんど溶けない。
効能
抗原虫薬
使用上の注意
アルゴン封入
説明
Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC₅₀ = 2.5 μM) and inhibits binding of [³H]mebendazole to H. contortus L3 larval tubulin (IC₅₀ = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC₅₀s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.
化学的特性
White Solid
使用
An anthelmintic.
定義
ChEBI: A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
一般的な説明
Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.