ラクトフェリン FROM HUMAN MILK 化学構造式

ラクトフェリン FROM HUMAN MILK

化学名:ラクトフェリン FROM HUMAN MILK

CAS番号.

英語名:LACTOFERRIN FROM HUMAN MILK

CBNumberCB2549716

MW0

MOL FileMol file

别名

ラクトフェリン FROM HUMAN MILK

ラクトフェリン FROM HUMAN MILK物理性質

貯蔵温度	2-8°C
溶解性	H₂O: 1 mg/mL
外見	凍結乾燥粉末
色	白から薄赤

安全性情報

主な危険性	B
Sフレーズ	22-24/25
WGK Germany	3

ラクトフェリン FROM HUMAN MILK 価格

製品番号	包装	価格	製品説明	購入
Sigma-Aldrich Japan L0520	5mg	￥23300	ラクトフェリン from human milk ≥85% (SDS-PAGE), lyophilized powder	購入
Sigma-Aldrich Japan L0520	25mg	￥46800	ラクトフェリン from human milk ≥85% (SDS-PAGE), lyophilized powder	購入
Sigma-Aldrich Japan L4894	5mg	￥25100	ラクトフェリン from human milk powder, BioReagent, suitable for cell culture	購入
Sigma-Aldrich Japan L4894	25mg	￥84700	ラクトフェリン from human milk powder, BioReagent, suitable for cell culture	購入
Sigma-Aldrich Japan L4894	100mg	￥284000	ラクトフェリン from human milk powder, BioReagent, suitable for cell culture	購入

ラクトフェリン FROM HUMAN MILK 化学特性,用途語,生産方法

使用
Lactoferrin from human milk has been used:
- to test its neuroprotective effect on neuroblastoma cells and mouse mesencephalic dopaminergic cell lines MN9D
- to test its antioxidative effect in Edible Bird′s Nest (EBN) induced toxicity in human neuroblastoma SH-SY5Y cells using oxygen radical absorbance capacity (ORAC) assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay
- in the preparation of immobilized titanium substrate for testingMG-63 osteoblast activity
- as a low-density lipoprotein (LDL) receptor-related protein (LRP1) ligand in vascular smooth muscle cells (VSMC)
一般的な説明
Lactoferrin is mapped to human chromosome 3p21.31. It comprises globular lobes and undergoes post-translational modifications like phosphorylation and glycosylation. Lactoferrin belongs to the lactotransferrin family and has Ser‐Lys catalytic dyad like serine proteases.
Biochem/physiol Actions
Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

ラクトフェリン FROM HUMAN MILK 生産企業

, ラクトフェリン FROM HUMAN MILK キーワード

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