SLP7111228 (hydrochloride)

SLP7111228 (hydrochloride) 化学特性,用途語,生産方法

• 説明

  SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with K_i values of 0.048 and >10 μM for SPHK1 and 2, respectively. It induces a concentration-dependent decrease in sphingosine-1-phosphate (S1P; ) in U937 cells but has no effect on sphingosine levels. In vivo, SLP7111228 decreases blood levels of S1P in a dose-dependent manner in rats.

SLP7111228 (hydrochloride) 生産企業

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