7-Dehydrocholesterol-25,26,26,26,27,27,27-d7

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 価格

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 化学特性,用途語,生産方法

• 使用

  7-dehydrocholesterol-d7 has been used:
  
  • as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis
  • in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
  • to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis
  
  

• 一般的な説明

  7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

• Biochem/physiol Actions

  7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).

7-Dehydrocholesterol-25,26,26,26,27,27,27-d7 生産企業

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