4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine 化学特性,用途語,生産方法

• 合成

  A solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine (70 g, 322.61 mmol) in THF (1.4 L) was treated with a solution of ethanolamine (32 g, 709.74 mmol, 46.37 mL) in THF (100 mL) at 0°C, dropwise under N2, over 1 hour. Once the addition was complete, the mixture was stirred at 25°C for 1 hour. The mixture was then filtered and concentrated under reduced pressure to obtain a residue. The residue was subsequently triturated with DCM (200 mL) and filtered. The filtrate was recrystallized with a mixture of n-heptane (600 mL) and MTBE (400 mL). The resulting phase was syrup-like in consistency, and the liquid phase was discarded. The syrup residue was further purified by silica gel column chromatography (PE: EtOAc=20:1) to yield 4-chloro-N-ethyl-5-(trifluoromethyl) pyrimidine-2-amine as a white solid.
  

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine 生産企業

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