ホキシム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H311：皮膚に接触すると有毒

  H317：アレルギー性皮膚反応を起こすおそれ

  H330：吸入すると生命に危険

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

ホキシム 価格

MSDS Information

• 4-Ethoxy-7-phenyl-3,5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile 4-sulfide

ホキシム 化学特性,用途語,生産方法

• 外観

  わずかにうすい黄色〜黄褐色, 澄明の液体

• 溶解性

  水1.5mg/l(20℃)。トルエン, n-ヘキサン,ジクロロメタン, イソプロパノール＞200g/l。水にほとんど溶けない。

• 効能

  駆虫薬 (獣医薬), アセチルコリンエステラーゼ阻害薬

• 農薬用途

  動物薬、殺虫剤

• 説明

  Phoxim is a light yellow liquid, Solubility in water is 1.5 mg/L (20 ?C). It is readily soluble in most organic solvents and slightly in aliphatic hydrocarbons. Log Kow = 3.38. It is relatively slowly hydrolyzed in aqueous media; DT₅₀ (22 ?C) at pH 4, 7, and 9 is 26.7, 7.2, and 3.1 d, respectively.

• 化学的特性

  yellowish oily liquid, Specific gravity: 1.176 (20°C)

• 使用

  Phoxim is used to control stored product insect pests in silos and barns. It is also used to control household insects such as ants and other public health pests. Agricultural targets include caterpillars and soil insects in maize, vegetables, cotton and potatoes.

• 安全性プロファイル

  Poison by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of CN-, NO,, PO,, and SO,. See also NITRILES.

• 代謝経路

  The primary metabolic step in the metabolism of phoxim in most biological systems is hydrolysis to the oxime, which may occur either oxidatively or via oxidative desulfuration followed by hydrolysis of the oxon which is much more hydrolytically labile. Stage II metabolism in plants involves the oxime group of the oxaminophenylacetonitrile moiety being reduced to an amine followed by its conjugation with malonic acid. Phoxim is one of a quite large group of insecticidal organophosphates which generates tetraethyl pyrophosphate and its thio analogues under the influence of light. These are compounds which are very active as acetylcholinesterase inhibitors and highly toxic to mammals.

• 代謝

  Phoxim is oxidatively desulfurated to the oxon, which inhibits housefly AChE 270 times as quickly as bovine AChE. In mammals, the oxon is immediately hydrolyzed into diethyl hydrogen phosphate. The direct cleavage of the oxime ester bond of phoxim, the hydrolytic transformation of the nitrile group into carboxyl, and deethylation also contribute to the low mammalian toxicity. Elimination is very quick, 97% of the dose being excreted in the urine and feces in 24 h. Degradation in soils is also very rapid. By photochemical reactions, the thiooxime phosphate isomer, tetraethyl pyrophosphate, and its monothio analog are produced in small amounts on foliage.

ホキシム 上流と下流の製品情報

ホキシム 生産企業

Global(206)Suppliers

ホキシム スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS)

14816-18-3, ホキシム キーワード