MK8245

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H242：熱すると火災のおそれ

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P234：他の容器に移し替えないこと。

  P235：涼しいところに置くこと。

  P240：容器を接地すること/アースをとること。

  P370+P378：火災の場合：消火に．．．を使用すること。

  P403：換気の良い場所で保管すること。

MK8245 化学特性,用途語,生産方法

• 説明

  MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC₅₀s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ⁵- and Δ⁶-desaturases (IC₅₀s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC₅₀ = 39.8 nM).

• 使用

  This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

MK8245 上流と下流の製品情報

MK8245 生産企業

Global(84)Suppliers

MK8245 スペクトルデータ(¹HNMR)

1030612-90-8, MK8245 キーワード