プラスミノーゲンアクチベーター阻害因子1(PAI-1) ヒト

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

プラスミノーゲンアクチベーター阻害因子1(PAI-1) ヒト 価格

プラスミノーゲンアクチベーター阻害因子1(PAI-1) ヒト 化学特性,用途語,生産方法

• 使用

  Plasminogen activator inhibitor 1 (PAI-1) human has been used:
  
  • as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes
  • to block plasmin activation in mice infected with C. albicans hyphae
  • to test its effect on neurite growth in neurons
  
  

• 一般的な説明

  Plasminogen activator inhibitor 1 (PAI-1) or serine protease inhibitor E1 (SERPINE1) gene is mapped to human chromosome 7q22.1. PAI-1 is produced in hepatocytes, endothelial cells, smooth muscle cells, megakaryocytes, and adipocytes.

• Biochem/physiol Actions

  Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.

プラスミノーゲンアクチベーター阻害因子1(PAI-1) ヒト 生産企業

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