1-(5-イソキノリンスルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン, DIHYDROCHLORIDE

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

1-(5-イソキノリンスルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン, DIHYDROCHLORIDE 価格

1-(5-イソキノリンスルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン, DIHYDROCHLORIDE 化学特性,用途語,生産方法

• 説明

  Rho-associated kinase (ROCK), an effector of the small GTP-binding protein Rho, plays an important role in various cellular functions including vascular smooth muscle contraction, proliferation, and migration as well as inflammatory cell mobility. HA-1077 is a potent inhibitor of ROCK2 and additionally inhibits protein kinase c-related kinase 2 (PRK2), mitogen- and stress-activated protein kinase (MSK1), and mitogen activated protein kinase-activated protein kinase 1b (MAPKAP-K1b) with IC₅₀ values of 1.9, 4, 5, and 15 μM, respectively. By inhibiting the activity of ROCK, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in various rodent models. While originally marketed for the prevention of cerebral vasospasm in patients with subarachnoid hemorrhage, oral formulations of HA-1077 are used for the treatment of a wide range of cardiovascular diseases including pulmonary arterial hypertension and stable angina.

• 化学的特性

  White fine crystalline powder

• 使用

  Fasudil dihydrochloride is used in the inhibition of contractile responses to potassium chloride, phenylephnne (PHE), prostaglandin and hepatic stellate cells spreading. It is also used in the formation of stress fibers and in medicine.

1-(5-イソキノリンスルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン, DIHYDROCHLORIDE 生産企業

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203911-27-7, 1-(5-イソキノリンスルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン, DIHYDROCHLORIDE キーワード