プロピオン酸ナトリウム水和物

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H312：皮膚に接触すると有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

プロピオン酸ナトリウム水和物 価格

プロピオン酸ナトリウム水和物 化学特性,用途語,生産方法

• 効能

  保存剤

• 化学的特性

  Sodium propionate occurs as colorless transparent crystals or as a granular, free-flowing, crystalline powder. It is odorless, or with a slight characteristic odor, and is deliquescent in moist air. Sodium propionate has a characteristic, slightly cheeselike taste, although by itself it is unpalatable.

• 使用

  Sodium Propionate Hydrate is a food preservative used for its antifungal ability towards grain products.

• 調製方法

  Sodium propionate is prepared by the reaction of propionic acid with sodium carbonate or sodium hydroxide.

• 応用例（製薬）

  As an excipient, sodium propionate is used in oral pharmaceutical formulations as an antimicrobial preservative. Like propionic acid, sodium propionate and other propionic acid salts are fungistatic and bacteriostatic against a number of Gram-positive cocci. Propionates are more active against molds than is sodium benzoate, but have essentially no activity against yeasts.
  Therapeutically, sodium propionate has been used topically in concentrations up to 10% w/w alone or in combination with other propionates, caprylates, or other antifungal agents, in the form of ointments or solutions for the treatment of dermatophyte infections. Eye drops containing 5% w/v sodium propionate have also been used.
  In food processes, particularly baking, sodium propionate is used as an antifungal agent; it may also be used as a flavoring agent in food products. In veterinary medicine, sodium propionate is used therapeutically as a glucogenic substance in ruminants.

• 安全性

  Sodium propionate and other propionates are used in oral pharmaceutical formulations, food products, and cosmetics. The free acid, propionic acid, occurs naturally at levels up to 1% w/w in certain cheeses.
  Following oral consumption, propionate is metabolized in mammals in a manner similar to that of fatty acids. Toxicity studies in animals have shown sodium propionate and other propionates to be relatively nontoxic materials.(2,3) In veterinary medicine, sodium propionate is used as a therapeutic agent for cattle and sheep.
  In humans, 6 g of sodium propionate has been administered daily without harm.(2) However, allergic reactions to propionates can occur.
  LD50 (mouse, oral): 6.33 g/kg
  LD50 (mouse, SC): 2.1 g/kg
  LD50 (rabbit, skin): 1.64 g/kg

• 貯蔵

  Sodium propionate is deliquescent and should therefore be stored in an airtight container in a cool, dry place.

• 不和合性

  Incompatibilities for sodium propionate are similar to those of other weak organic acids.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted for use as a food additive in Europe. In cheese products, propionates are limited to 0.3% w/w concentration; a limit of 0.32% w/w is applied in flour and white bread rolls, while a limit of 0.38% w/w is applied in whole wheat products.
  Included in the FDA Inactive Ingredients Database (oral capsules, powder, suspensions, and syrups). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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