アムルビシン塩酸塩

アムルビシン塩酸塩 化学特性,用途語,生産方法

• 効能

  抗悪性腫瘍薬, トポイソメラーゼII阻害薬

• 商品名

  カルセド (大日本住友製薬)

• 説明

  small and small-cell lung cancers. Amrubicin, a completely synthetic anthracycline derivative, mediates its growth inhibitory action via topoisomerase II inhibition. It is activated in viva by the formation of its 13-OH metabolite, amrubicinol, via reaction with carbonyl reductase. In contrast to doxorubicin and daunorubicin whose metabolites are inactive in the blood, amrubicinol is 10-100 fold more cytotoxic than amrubicin. In phase II clinical trials, amrubicin showed antitumor activity against non-small-cell lung cancers (response rate exceeding 20%) and against untreated extensive stage small-cell-lung cancers (response rate 78.8%). Amrubicin demonstrated a smaller distribution-volume, a shorter half-life in mice and also less chronic cardiotoxicity in preclinical studies compared to doxorubicin. Amrubicin was generally well tolerated with major adverse events being anaemia, leucopenia, thrombocytopenia and neutropenia.

• Originator

  Sumitomo (Japan)

• brand name

  Calsed

アムルビシン塩酸塩 生産企業

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