サケカルシトニン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

サケカルシトニン 価格

サケカルシトニン 化学特性,用途語,生産方法

• 外観

  本品は白色の粉末である．
  本品は水に溶けやすい．
  本品は希酢酸に溶ける．
  本品20mgを水2mLに溶かした液のpHは5.0～7.0である．
  本品は吸湿性である．

• 効能

  骨吸収抑制薬, カルシウム制御薬

• 確認試験

  本品1mgを希酢酸1mLに溶かした液につき，紫外 可視吸光度測定法により吸収スペクトルを測定し， 本品のスペクトルと本品の参照スペクトルを比較するとき， 両者のスペクトルは同一波長のところに同様の強度の吸収を 認める．

• 貯法

  保存条件 遮光して，10℃以下で保存する．
  容器 密封容器．

• 説明

  Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.

• 化学的特性

  White or almost white powder.

• 使用

  Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).

• 臨床応用

  Only salmon CT is commercially available for medical use, because on a weight basis, it is approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved for treating Paget's disease of bone (generally seen in older persons; involves increased bone resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy (multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.

サケカルシトニン 生産企業

Global(384)Suppliers

サケカルシトニン スペクトルデータ(MS)

47931-85-1, サケカルシトニン キーワード