トランスフェリン,ホロ-

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

トランスフェリン,ホロ- 価格

トランスフェリン,ホロ- 化学特性,用途語,生産方法

• 外観

  白色〜うすい褐色, 結晶〜粉末

• 溶解性

  水に溶ける。

• 特長

  再生医療等製品材料適格性相談済、確認書取得済。

• 特長

  製造工程中に動物由来物を使用していません。

• 使用上の注意

  不活性ガス封入

• 説明

  Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.

• 使用

  Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

• 一般的な説明

  Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

• 応用例（製薬）

  Transferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+, as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated phenol groups, a carboxylate and a carbonato ligand.

• 純化方法

  This transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.]

• 参考文献

  https://en.wikipedia.org/wiki/Transferrin
  http://www.prospecbio.com/Holo_Transferrin_Human_11_121/

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