2-ブロモプロパン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

2-ブロモプロパン 価格

MSDS Information

• 2-Bromopropane

2-ブロモプロパン 化学特性,用途語,生産方法

• 外観

  無色～ほとんど無色, 澄明の液体

• 溶解性

  水に微溶, エタノール, エーテルに易溶。エタノール及びアセトンに極めて溶けやすく、水に極めて溶けにくい。

• 用途

  本物質の主な用途、排出源は合成原料(医薬中間体、農薬中間体、感光剤中間)とされている

• 説明

  2-Bromopropane, also known as isopropyl bromide and 2-propyl bromide, is the halogenated hydrocarbon with the formula CH3CHBrCH3. It is a colorless liquid. It is used for introducing the isopropyl functional group in organic synthesis. 2-Bromopropane is prepared by heating isopropanol with hydrobromic acid.

• 化学的特性

  colourless liquid

• 使用

  2-Bromopropane is a general reagent used to introduce isopropyl group as in the case of the synthesis of various Buchwald ligands. It can also be used as a starting material in the total synthesis of lamellarin D, lamellarin H, ningalin B and (±)-dichroanal. It is sometimes used as an alternative to ozone-depleting cleaning solvents such as chlorofluorocarbons.

• 製造方法

  2-Bromopropane is commercially available. It may be prepared in the ordinary manner of alkyl bromides, by reacting isopropanol with phosphorus and bromine, or with phosphorus tribromide.

• 健康ハザード

  2-bromopropane, apparently caused ovarian failure, azoospermia, oligospermia, and anemia in a group of Korean workers. Experimental studies confirm specific reproductive effects in females and males. Hematopoietic effects and peripheral neuropathy also have been reported in animal studies. There is limited evidence of adverse effects in exposed workers similar to those seen in animals.

• 安全性プロファイル

  Moderately toxic by intraperitoneal route. A very flammable liquid and dangerous fire hazard. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.

• 純化方法

  Wash the bromide with 95% H2SO4 (concentrated acid partially oxidised it) until a fresh portion of acid did not become coloured after several hours, then with water, aqueous NaHSO3, aqueous 10% Na2CO3 and again with water. (The H2SO4 can be replaced by conc HCl.) Prior to this treatment, isopropyl bromide has been purified by bubbling a stream of oxygen containing 5% ozone through it for 1hour, followed by shaking with 3% hydrogen peroxide solution, neutralising with aqueous Na2CO3, washing with distilled water and drying. Alternatively, it has been treated with elemental bromine and stored for 4 weeks, then extracted with aqueous NaHSO3 and dried with MgSO4. After the acid treatment, isopropyl bromide can be dried with Na2SO4, MgSO4 or CaH2, and fractionally distilled. [Beilstein 1 IV 208.]

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2-ブロモプロパン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

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