アセトンシアンヒドリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

  H310：皮膚に接触すると生命に危険

  H330：吸入すると生命に危険

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P262：眼、皮膚、衣類につけないこと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P271：屋外または換気の良い場所でのみ使用すること。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P284：呼吸用保護具を着用すること。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P302+P350：皮膚に付着した場合：多量の水と石鹸で優しく洗うこと。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P310：ただちに医師に連絡すること。

  P320：特別な治療が緊急に必要である（このラベ ルの．．．を見よ）。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P322：特別な処置が必要である（このラベルの．．． を見よ）。

  P330：口をすすぐこと。

  P361：汚染された衣類をすべて脱ぐこと。

  P363：汚染された衣類を再使用す場合には洗濯をすること。

  P391：漏出物を回収すること。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

アセトンシアンヒドリン 価格

MSDS Information

• 2-Hydroxy-2-methylpropionitrile

アセトンシアンヒドリン 化学特性,用途語,生産方法

• 用途

  メタクリル樹脂の中間体原料

• 説明

  Acetone cyanohydrin is an organic compound used in the production of methyl methacrylate, the monomer of the transparent plastic polymethyl methacrylate (PMMA), also known as acrylic. Acetone cyanohydrin is a flammable colourless liquid with a faint odour of bitter almond. It is incompatible with sulphuric acid. Acetone cyanohydrin readily undergoes decomposition by water to form hydrogen cyanide and acetone. Cassava tubers contain linamarin, a glucoside of acetohydrin, and the enzyme linamarinase for hydrolysing the glucoside. Crushing the tubers releases these compounds and produces acetone cyanohydrin, which is potentially lethally toxic. Acetone cyanohydrin is classified as an extremely hazardous substance in the U.S. Emergency Planning and Community Right-to- Know Act. The principal hazards of acetone cyanohydrin arise from its ready decomposition on contact with water, which releases highly toxic hydrogen cyanide.

• 化学的特性

  Acetone cyanohydrin is a flammable, colorless to light yellow liquid. Almond-like odor.

• 使用

  Acetone cyanohydrin is used to make methyl methacrylate; in the production of pharmaceuticals, foaming agents, and insecticides; and to produce polymerization initiators.

• 調製方法

  Acetone cyanohydrin is formed by adding acetone to sodium or potassium cyanide in water and treating with H₂S0₄ or by reaction of acetone with hydrogen cyanide (HSDB 1988; Windholz et al 1983). Technical acetone cyanohydrin may contain as much as 0.2% free hydrogen cyanide. U.S. production in 1984 is estimated at 546,000 tons (HSDB 1988).

• 一般的な説明

  A colorless liquid. Flash point 165°F. Lethal by inhalation and highly toxic or lethal by skin absorption. Density 7.8 lb / gal (less dense than water). Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

• 反応プロフィール

  ACETONE CYANOHYDRIN readily decomposes to acetone and poisonous hydrogen cyanide gas on contact with water, acids (sulfuric acid) or when exposed to heat. Should be kept cool and slightly acidic (pH 4-5) [Sax, 2nd ed., 1965, p. 388]. Slowly dissociates to acetone, a flammable liquid, and hydrogen cyanide, a flammable poisonous gas, under normal storage and transportation conditions. Rate of dissociation increased by contact with alkalis and/or heat.

• 健康ハザード

  Acetone cyanohydrin is considered very hazardous and should only be handled under conditions that prevent any inhalation of vapor or skin contact. May be slightly irritating to skin and mucous membranes.

• 火災危険

  Too dangerous to health to expose fire fighters; a few whiffs of vapor could cause death; vapor or liquid could be fatal on penetrating normal protective clothing. Vapor forms explosive mixture with air. Decomposes when heated to 248F or at lower temperature under alkaline conditions, emitting highly toxic hydrogen cyanide. May react violently with water. Contact with sulfuric acid may cause Acetone cyanohydrin to explode.

• 工業用途

  Actone cyanohydrin is used primarily in the preparation of methyl methacrylate, which is polymerized to form various plastics, including plexiglas, and as intermediate for resins (Hawley 1981). It also is employed for the manufacture of insecticides; to produce oc-hydroxy-isobutyrate, a pharmaceutical intermediate; as a complexing agent for metals; and as a reagent for chemical synthesis.

• 安全性プロファイル

  Poison by ingestion, skin contact, inhalation, intraperitoneal, and subcutaneous routes. Readily decomposes to HCN and acetone. Keep cool and do not store for long periods. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical, alcohol foam. Vigorous reaction with H2SO4. When heated to decomposition it emits toxic fumes of CN-.

• 職業ばく露

  Used in the manufacture of insecticides and making other chemicals, such as methyl methacrylate.

• 代謝

  Acetone cyanohydrin is readily absorbed by all routes (Hartung 1981). Shkodich (1966) found no evidence of cumulative effects of acetone cyanohydrin in white mice or albino rats over a period of 20 d in which daily doses of one-fifth of the LD₅₀s were given. Rapid detoxication and excretion were presumed to occur. Acetone cyanohydrin may be largely metabolized to yield free cyanide (H?rtung 1981).

• 輸送方法

  UN1541 Acetone cyanohydrin, stabilized, Hazard Class: 6.1; Labels: 6.1-Poison Inhalation Hazard, Inhalation Hazard Zone B.

• 純化方法

  Dry the cyanohydrin with Na2SO4, and distil it as rapidly as possible under vacuum to avoid decomposition. Discard fractions boiling below 78-82o/15mm. Store it in the dark. USE AN EFFICIENT FUME HOOD as HCN (POISONOUS) is always present. [Cox & Stormont Org Synth Coll.Vol. II 7 1940, Beilstein 3 H 316, 3 IV 785.]

• 不和合性

  May form explosive mixture with air. Not compatible with strong reducers, strong bases; strong oxidizers, and strong acids, such as hydrochloric, sulfuric (explosive), and nitric. Contact with strong acid and strong bases may cause explosions. Slowly decomposes to acetone and hydrogen cyanide gas at room temperatures; rate is accelerated by an increase in pH, contact with water, or temperature.

• 廃棄物の処理

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Add with stirring to strong alkaline calcium hypochlorite solution. Alternatively dissolve in flammable solvent and burn in incinerator with afterburner and scrubber.

アセトンシアンヒドリン 上流と下流の製品情報

アセトンシアンヒドリン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS)

75-86-5, アセトンシアンヒドリン キーワード