1H-ピロロ[2,3-b]ピリジン

化学名:1H-ピロロ[2,3-b]ピリジン

CAS番号.271-63-6

英語名:7-Azaindole

CBNumberCB1664663

MFC7H6N2

MW118.14

别名

1H-ピロロ[2,3-b]ピリジン

7H-ピロロ[2,3-b]ピリジン

7-アザ-1-ピリンジン

1H-ピロロ[2,3-b]ピリジン物理性質

融点	105-107 °C (lit.)
沸点	270 °C (753.1004 mmHg)
比重(密度)	1.1151 (rough estimate)
屈折率	1.5500 (estimate)
闪点	270°C
貯蔵温度	Sealed in dry,Room Temperature
溶解性	クロロホルム、メタノール
酸解離定数(Pka)	7.69±0.20(Predicted)
外見	粉
色	ホワイトからオフホワイト
BRN	109667
InChIKey	MVXVYAKCVDQRLW-UHFFFAOYSA-N
CAS データベース	271-63-6(CAS DataBase Reference)
NISTの化学物質情報	1H-Pyrrolo[2,3-b]pyridine(271-63-6)
EPAの化学物質情報	1H-Pyrrolo[2,3-b]pyridine (271-63-6)

安全性情報

危険有害性情報のコード(GHS)

外観
白色～微黄色の結晶又は結晶性粉末
用途
有機合成原料。
化学的特性
Brown-Cyrstalline Solid
使用
7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.
A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.
主な応用
7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.
製造方法
Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.
純化方法
Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]