ヘキセチジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

ヘキセチジン 価格

ヘキセチジン 化学特性,用途語,生産方法

• 効能

  消毒薬

• 化学的特性

  Hexetidine is a colorless or faint yellow-colored oily liquid with a characteristic amine odor.

• 使用

  Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.

• 調製方法

  Hexetidine is prepared by hydrogenation under pressure of 1,3- bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C using Raney nickel as a catalyst.

• 一般的な説明

  The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.

• 危険性

  Combustible.

• 応用例（製薬）

  Hexetidine is used as an antimicrobial preservative in cosmetics and nonparenteral pharmaceutical formulations. Therapeutically, hexetidine is mainly used as a 0.1% w/v solution in mouthwash formulations for the prevention and treatment of minor local infections, gingivitis, and mouth ulcers.

• 安全性

  Hexetidine is mainly used in mouthwashes as a bactericidal and fungicidal antiseptic. It is also used as an antimicrobial preservative and is generally regarded as a relatively nontoxic and nonirritant material at concentrations up to 0.1% w/v. Allergic contact dermatitis and altered olfactory and taste perception have occasionally been reported. Hexetidine is toxic when administered intravenously.
  Solutions of hexetidine in oil at concentrations of 5–10% w/v cause strong primary irritations without sensitization in humans. Long-term toxicological studies of up to 0.1% w/w of hexetidine in food for 1 year do not show any toxic effect. Fetotoxicity, embryotoxicity, and teratogenicity studies in rats of doses up to 50 mg/kg/day exhibit no sign of toxicity.
  LD100 (cat, IV): 5–20 mg/kg
  LD50 (dog, oral): 1.60 g/kg
  LD50 (mouse, IP): 0.142 g/kg
  LD50 (mouse, oral): 1.52 g/kg
  LD50 (rat, oral): 0.61–1.43 g/kg

• 貯蔵

  Hexetidine is stable and should be stored in a well-closed container in a cool, dry place. Brass and copper equipment should not be used for the handling or storage of hexetidine.

• 不和合性

  Hexetidine is incompatible with strong oxidizing agents. Salts are formed with mineral and organic acids; strong acids cause opening of the hexahydropyrimidine ring, releasing formaldehyde.

• 規制状況(Regulatory Status)

  Included in nonparenteral formulations licensed in Europe.

ヘキセチジン 上流と下流の製品情報

ヘキセチジン 生産企業

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141-94-6, ヘキセチジン キーワード