ANTI-GLUTAMATE RECEPTOR 6, METABOTROPIC

ANTI-GLUTAMATE RECEPTOR 6, METABOTROPIC 価格

ANTI-GLUTAMATE RECEPTOR 6, METABOTROPIC 化学特性,用途語,生産方法

• 一般的な説明

  L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. (provided by RefSeq)

ANTI-GLUTAMATE RECEPTOR 6, METABOTROPIC 生産企業

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