METHYL (1-TRIMETHYLSILYL)ACRYLATE

METHYL (1-TRIMETHYLSILYL)ACRYLATE 化学特性,用途語,生産方法

• 物理的性質

  bp 75 °C/50 mmHg, 152 °C/690 mmHg.

• 使用

  Methyl 2-Trimethylsilylacrylate is widely used as reactive, α-silyl Michael acceptor for conjugate addition of carbanions, enolate anions, organolithium reagents, and Grignard reagents; affords 3-cyclopentenecarboxylates and cyclohexanecarboxylates by [3 + 2] and [4 + 2] annulation methods; provides α-silyl esters and vinylsilanes by organolithium conjugate additions.

• 製造方法

  Methyl 2-Trimethylsilylacrylate is prepared by the reaction of (E)-2- (trimethylsilyl)vinyllithium with methyl chloroformate or by carbonation of the corresponding Grignard reagent prepared from (1-bromovinyl)trimethylsilane, giving 2-trimethylsilylacrylic acid. The methyl ester is prepared from the acid by direct esterification with absolute methanol in the presence of mineral acid, by reaction with diazomethane at low temperature, or by treatment with BF3·MeOH complex.

METHYL (1-TRIMETHYLSILYL)ACRYLATE 生産企業

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