シアノホスホン酸ジエチル

化学名:シアノホスホン酸ジエチル

CAS番号.2942-58-7

英語名:Diethyl cyanophosphonate

CBNumberCB1420852

MFC5H10NO3P

MW163.11

别名

シアノホスホン酸ジエチル

ジエチルシアノホスホン酸

シアノホスホン酸ジエチル物理性質

沸点	104-105 °C19 mm Hg(lit.)
比重(密度)	1.075 g/mL at 25 °C(lit.)
屈折率	n20/D 1.403(lit.)
闪点	177 °F
貯蔵温度	2-8°C
溶解性	Acetonitrile (Slightly), Chloroform (Slightly)
外見	液体
比重	1.075
色	無色透明～黄色
水溶解度	分解する
Sensitive	Moisture Sensitive
BRN	1768938
暴露限界値	NIOSH: IDLH 25 mg/m3
安定性：	Moisture Sensitive
CAS データベース	2942-58-7(CAS DataBase Reference)
NISTの化学物質情報	Diethyl cyanophosphonate(2942-58-7)

安全性情報

危険有害性情報のコード(GHS)

外観
無色～黄褐色, 澄明の液体
溶解性
有機溶媒に易溶。エタノール及びアセトンに極めて溶けやすく、水で徐々に分解する。
用途
ペプチドのカルボキシル基を活性化し、酸アミド結合を形成させる縮合剤。
化学的特性
Diethyl cyanophosphonate is a clear colourless to yellow liquid. It soluble in most common organic solvents , such as dimethylformamide , tetrahydrofuran , diethyl ether , and toluene. Diethyl cyanophosphonate is highly toxic and corrosive. lt must be handled in awell-ventilated fume hood. In addition, it is moisture sensitive and should bestored in a refrigerator under nitrogen.
使用
Diethyl cyanophosphonate was used in the synthesis of 4-acylthiol-4-deoxy-4′-demethyl epipodophyllotoxin analogs. Coupling reagent for peptide synthesis. Reagent for the phosphorylation of phenols. Activating agent for fluorescent derivatization of carboxylic acids which allows separation by HPLC.
一般的な説明
Diethyl cyanophosphonate (DCNP, a Tabun mimic, DECP) is a nerve agent simulant. Its detection by using fluorescein, a reversible fluorescent sensor, has been reported. Its degradation in the presence of suitable organocatalysts (different amines, aminoalcohols and glycols) has been studied.
参考文献
[1] Shinya Harusawa , Takayuki Shioiri. “Diethyl phosphorocyanidate (DEPC): a versatile reagent for organic synthesis.” Tetrahedron 72 50 (2016): Pages 8125-8200.