リセドロン酸ナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

リセドロン酸ナトリウム 価格

リセドロン酸ナトリウム 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄色, 結晶〜粉末

• 溶解性

  水に溶け、エタノール及びアセトンにほとんど溶けない。

• 用途

  ビスフォスフォネート系化合 物です。破骨細胞が付着する骨石灰化面に選 択的に分布し、骨吸収を抑制します。

• 用途

  ビスフォスフォネート系化合 物です。破骨細胞が付着する骨石灰化面に選 択的に分布し、骨吸収を抑制します。

• 効能

  骨吸収抑制薬, 骨粗鬆症治療薬, ファルネシルピロリン酸合成酵素阻害薬

• 説明

  Risedronate sodium was launched as Actonel in the US for treatment of Paget's disease. Risedronic acid is readily obtained by condensation of 2-(3- pyridyl)acetic acid with phosphorous acid in presence of phosphorus oxychloride. Risedronate sodium is an orally active bisphosphonate of third generation, showing more potent bone antiresorptive properties than most of prior bisphosphonates like etidronate which has been used for the same indication since 1978. The biological mechanism by which Risedronate, and generally bisphosphonates, act is not quite clear presently ; recent advances have suggested that aminobisphosphonates interfere with the HMG-CoA pathway and inhibit protein prenylation, causing apoptosis of osteoclasts and macrophages. These apoptotic effects are correlated to the anti-resorptive properties of this class of compounds. In a 2 month clinical trial involving patients with Paget's desease, 30 mg risedronate daily achieved an appreciable reduction of serum alkaline phosphatase levels, an indicator of bone stabilization, in 77% of patients, compared with 11% on etidronate at 400 mg daily for 6 months. Risedronate is also in development for the treatment and prevention of various bone diseases, particularly post-menopausal and corticosteroid-induced osteoporosis.

• 化学的特性

  Fine White to Off-White Crystalline Powder

• 使用

  Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor.

• 危険性

  Human systemic effects.

• 生物活性

  Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo .

リセドロン酸ナトリウム 生産企業

Global(402)Suppliers

リセドロン酸ナトリウム スペクトルデータ(¹HNMR)

115436-72-1, リセドロン酸ナトリウム キーワード