4-アミノ-m-クレゾール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4-アミノ-m-クレゾール 価格

MSDS Information

• 4-Amino-m-cresol

4-アミノ-m-クレゾール 化学特性,用途語,生産方法

• 外観

  白色〜褐色, 結晶性粉末

• 溶解性

  水、エタノール及びアセトンに溶ける。

• 用途

  有機合成原料。

• 説明

  4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

• 化学的特性

  Light gray powder

• 使用

  4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
  4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.

• 主な応用

  4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.

• 定義

  ChEBI: 4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.

• 一般的な説明

  4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

• 合成

  The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl₂ (0.72 g, 3.80 mmol), 20 mL of CH₂Cl₂, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH₂Cl₂ was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO₃. The organic layer was dried over anhydrous Na₂SO₄ and the filtrate was concentrated under reduced pressure to afford the solid product.
  

• 純化方法

  Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]

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