トリホスアデニン二ナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

トリホスアデニン二ナトリウム 価格

MSDS Information

• Adenosine 5'-triphosphate disodium salt

トリホスアデニン二ナトリウム 化学特性,用途語,生産方法

• 定義

  本品は、アデノシン三リン酸(*)の二ナトリウム塩である。参照表示名称：アデノシン三リン酸

• 無機性値/有機性値

  2385/200

• 化粧品の成分用途

  皮膚コンディショニング剤

• 効能

  鎮暈薬, 代謝賦活薬

• 商品名

  ATP (アルフレッサファーマ); ATP (第一三共); アデホス (興和); アデホス (興和); アデホス−L (興和); トリノシン (トーアエイヨー); トリノシン (トーアエイヨー); トリノシン (トーアエイヨー)

• 説明

  ATP disodium salt (Adenosine 5'-triphosphate disodium salt, ATP-Na2) is an organic sodium salt. It consists of an ATP and a ({(2R,3S,4R,5R)-3,4-dihydroxy-5-(9h -purin-9-yl)oxolan-2-yl)methylphosphonatooxy)phosphonate. It has the role of providing a source of energy for cells and is a central component of energy storage and metabolism in the body. ATP disodium salt is an important endogenous signalling molecule in immunity and inflammation. It is an important component in the study of various physiological and biochemical processes. It is involved in a variety of cellular functions such as muscle contraction, nerve impulse transmission and membrane transport, making it a fundamental molecule for understanding biological mechanisms. It can also be used to photometrically determine Luc activity in cell extracts.

• 化学的特性

  White powder

• 使用

  A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt (ATP-Na2) is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.

• 生物活性

  P2 purinoceptor agonist.

• in vitro

  ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on activating the NLRP3 inflammasome in HGFs.
  ATP disodium salt (2 mM; 0.5-24 hours) induces the secretion of interleukin 1β, KC, and MIP-2 from bone marrow-derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.
  ATP disodium salt stimulates cytokine and chemokine secretion, and inflammasome activation, directly and indirectly, induces in vitro neutrophil chemotaxis.

• Toxicity evaluation

  ATP disodium salt (ATP-Na2) was administered by gavage to rats for 90 consecutive days at doses of 0 (control), 500, 1000, and 2000 mg kg BW1·d1 (n = 10 per sex/group). Subchronic administration of ATP was well tolerated at all dose levels. Body weights and feed consumption body weight gains were similar between ATP-treated and control rats. Minor differences were seen in hematology and blood chemistry; however, these changes were not dose-related and, therefore, not of biological or toxicological significance. Only one difference was observed in absolute organ weights; females of the high dose had increased kidney and increased relative kidney and liver weights; however, these differences were not seen in males nor appeared to be dose-related[1].

トリホスアデニン二ナトリウム 生産企業

Global(733)Suppliers

トリホスアデニン二ナトリウム スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

987-65-5, トリホスアデニン二ナトリウム キーワード