抗MCL1抗体 ウサギ宿主抗体

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H412：長期的影響により水生生物に有害

• 注意書き

  P273：環境への放出を避けること。

抗MCL1抗体 ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
  Immunocytochemistry (1 paper)
  Immunohistochemistry (1 paper)

• 一般的な説明

  Induced myeloid leukemia cell differentiation protein Mcl-1(MCL1) belongs to the Bcl-2 family and contains the characteristic Bcl-2 homology (BH) domain. The gene encoding this protein is present on chromosome 1q21.

• Biochem/physiol Actions

  Induced myeloid leukemia cell differentiation protein Mcl-1(MCL1) plays an important role in inhibiting apoptosis and is expressed only during particular stages of cell differentiation and in response to specific signals. It is a viability-promoting protein that interacts with fortilin (an anti-apoptotic protein) and regulates cell viability. Specific differentiation- and apoptosis-inducing stimuli enhance the expression of this protein. MCL1 acts as a chaperone of fortilin by binding and stabilizing it. It also interacts and negatively regulates the proliferating cell nuclear antigen (PCNA), which a cell cycle-regulatory protein essential for G1 to S phase transition. Hence, it functions to retard the cell cycle progression.

抗MCL1抗体 ウサギ宿主抗体 生産企業

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