MATRIX METALLOPROTEINASE-1 ヒト

MATRIX METALLOPROTEINASE-1 ヒト 価格

MATRIX METALLOPROTEINASE-1 ヒト 化学特性,用途語,生産方法

• 使用

  Matrix metalloproteinase-2 (MMP2) human has been used:
  
  • As a standard in zymography to measure gelatinolytic activity of MMP2.
  • In enzymatic method for dissociation of brain tissue to single cells.

• 一般的な説明

  Matrix metalloproteinase-2 (MMP-2) also known as gelatinase or type IV collagenase is a 72kDa protein. MMP-2 is a member of matrix metalloproteinase (MMP) family of enzymes. Basic structure of MMP2 contains signal peptide domain that targets the enzyme for secretion, the pro-peptide domain, which is removed when the enzyme is activated and the catalytic site containing gelatin-binding domain.

• Biochem/physiol Actions

  Matrix Metalloproteinase-2 (MMP-2) cleaves gelatin, type IV, V, VII, X, and XI collagens, fibronectin, elastin, laminin, proteoglycans and a range of non extracellular matrix (ECM ) components. MMP-2 cleaves native type I collagen to N-terminal ? and C-terminal ? fragments identical to those generated by interstitial collagenases. MMP2 and MMP9 play an essential role in matrix degradation and they are implicated in the maintenance of neovascularization. In mice, deletion or inhibition of MMP2 protects against myocardial rupture.

MATRIX METALLOPROTEINASE-1 ヒト 生産企業

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MATRIX METALLOPROTEINASE-1 ヒト スペクトルデータ(¹HNMR)

193807-58-8, MATRIX METALLOPROTEINASE-1 ヒト キーワード