VR23

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

VR23 化学特性,用途語,生産方法

• 説明

  VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC₅₀s = 1 nM, 50-100 nM, and 3 μM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively). It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells. In combination with the chymotrypsin-like proteasome inhibitor bortezomib , VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.

• 使用

  VR23 is a quinoline-sulfonyl hybrid proteasome inhibitor which is used in cancer therapeutics. Targets cancer via cycline E-mediated centrosome.

VR23 生産企業

Global(81)Suppliers

VR23 スペクトルデータ(¹HNMR)

1624602-30-7, VR23 キーワード