3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 価格

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 化学特性,用途語,生産方法

• 説明

  Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC₅₀ = 1.3 μM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.

• 使用

  Aureusimine B is a novel small molecule isolated from S. aureus as one of a pair of related metabolites controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B has also been reported as an inhibitor of the protease, calpain.

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 生産企業

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3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone スペクトルデータ(¹HNMR)