1,4-dihydronicotinaMide riboside

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

1,4-dihydronicotinaMide riboside 化学特性,用途語,生産方法

• 使用

  Reduced Nicotinamide Riboside is a precursor which is an essential cofactor and substrate for many cells.

• 生物活性

  1,4-dihydronicotinamide riboside (NRH) is a potent NAD+ concentration enhancer both in vitro and in vivo. Researchers found that, after administration of NRH to mammalian cells, the NAD+ concentration increased by 2.5–10fold over control values in just one hour. Their findings demonstrate that the use of NRH is more effective than either NR or NMN. Moreover, NRH considerably enhances the NAD+/NADH ratio in the cultured cells without induction of apoptotic markers or a substantial increase in cell lactate levels. More recently, Canto et al. have found that contrary to the NR pathway, NRH uses different steps and enzymes to synthesize NAD+. That explains why NRH is a more effective and faster NAD+ precursor than NR in mammalian cells. In experiments with mice, the same researchers have also demonstrated that NRH is orally bioavailable as an NAD+ precursor and prevents cisplatin-induced acute kidney injury. In addition to increasing NAD+ levels, NRH can also deplete some genotoxins, such as hydrogen peroxide and methylmethane sulfonate. As a result, the mouse cells treated with NRH are resistant to cell death[1].

1,4-dihydronicotinaMide riboside 上流と下流の製品情報

1,4-dihydronicotinaMide riboside 生産企業

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