IWP-2

IWP-2 価格

IWP-2 化学特性,用途語,生産方法

• 外観

  白色～うすい褐色, 結晶～粉末

• 溶解性

  DMSO(1mg/mL)ジメチルスルホキシドに溶け、水、エタノール及びアセトンにほとんど溶けない。

• 特長

  細胞培養用途に安心して使用できるように、マイコプラズマ試験、細胞毒性確認済み。

• 使用上の注意

  不活性ガス封入

• 使用

  IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

• 一般的な説明

  A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).

• Biochem/physiol Actions

  IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts.

IWP-2 生産企業

Global(135)Suppliers

IWP-2 スペクトルデータ(¹HNMR)

686770-61-6, IWP-2 キーワード