3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 化学特性,用途語,生産方法

• 一般的な説明

  A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC₅₀ = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC₅₀ = 75 μM for MCF-10A and 63 μM for MCF-12A).

• Biochem/physiol Actions

  Cell permeable: yes

3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 生産企業

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562823-84-1, 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE キーワード