モノクローナル抗サイトケラチン, PAN(混合)抗体 マウス宿主抗体

モノクローナル抗サイトケラチン, PAN(混合)抗体 マウス宿主抗体 価格

モノクローナル抗サイトケラチン, PAN(混合)抗体 マウス宿主抗体 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-Cytokeratin, pan?FITC antibody has been used in immunocytochemistry and has also been used to visualize lung epithelial cells.

• 一般的な説明

  Monoclonal Anti-Pan Cytokeratin (mouse IgG1 isotype) is derived from the PCK-26 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a cytokeratin preparation from human epidermis. Cytokeratins are a group of at least 29 different proteins. They are characteristic of epithelial and trichocytic cells. Cytokeratin peptide 1 (68 kDa) is expressed together with cytokeratin 10 in the suprabasal cell layers or the differentiation compartment of the epidermis. Its expression increases with epidermal maturation and is modified post translationally in terminally differentiated keratinocytes of the stratum corneum. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification.

• Biochem/physiol Actions

  Cytokeratins helps in subtyping several kinds of epithelial differentiation or for narrowing possible sites of origin for metastatic carcinomas. Cytokeratins may play an important role in transhepatic transport and canalicular secretion.

モノクローナル抗サイトケラチン, PAN(混合)抗体 マウス宿主抗体 生産企業

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