フルスルチアミン

化学名:フルスルチアミン

CAS番号.804-30-8

英語名:Fursultiamine

CBNumberCB1161096

MFC17H26N4O3S2

MW398.54

别名

チアミンテトラヒドロフルフリルジスルフィド

アリナキシンF

N-[(4-アミノ-2-メチル-5-ピリミジニル)メチル]-N-[4-ヒドロキシ-1-メチル-2-[[(テトラヒドロフラン-2-イル)メチル]ジチオ]-1-ブテニル]ホルムアミド

フルスルチアミン物理性質

融点	130-136°C (decompos.)
沸点	652.3±55.0 °C(Predicted)
比重(密度)	1.29
屈折率	1.6270 (estimate)
貯蔵温度	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解性	エタノール、DMSO、ジメチルホルムアミド（DMF）などの有機溶媒に可溶。
外見	個体
酸解離定数(Pka)	14.42±0.10(Predicted)
色	ホワイトからオフホワイト
CAS データベース	804-30-8(CAS DataBase Reference)

安全性情報

毒性	LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

フルスルチアミン化学特性,用途語,生産方法

効能
ビタミンB1補充薬
商品名
アリナミン (武田テバ薬品)
説明
Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.
化学的特性
white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.
使用
Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.
主な応用
Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.
製造方法
Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.