RN1734

RN1734 価格

RN1734 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色、結晶性粉末～粉末

• 溶解性

  ジメチルスルホキシド溶状：試験適合

• 使用

  RN 1734 is a novel TRPV4 modulator.

• 一般的な説明

  A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca²⁺ influx (IC₅₀ = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC₅₀ >30 μM).

• 生物活性

  Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

RN1734 生産企業

Global(76)Suppliers

RN1734 スペクトルデータ(¹HNMR)

946387-07-1, RN1734 キーワード