3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 価格

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 化学特性,用途語,生産方法

• 使用

  O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

• 一般的な説明

  Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.

• Biochem/physiol Actions

  OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE 生産企業

Global(40)Suppliers

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE スペクトルデータ(¹HNMR)

350997-39-6, 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE キーワード