ニコチンアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

ニコチンアミド 価格

MSDS Information

• 3-Pyridinecarboxamide

ニコチンアミド 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 定義

  本品は、次の化学式で表される複素環式芳香族アミドである。

• 性質

  無色針状晶(ベンゼンから)．mp. 128～131 °C．pK 10.6，13.5．λmax　261.5 nm，εはpH により変化．乾燥固体は50 °C以下安定．水溶液120 °C，20 min安定．酸性・アルカリ性で加水分解

• 溶解性

  水又はエタノールに易溶, ジエチルエーテルに難溶。

• 解説

  ニコチン酸アミド．3-pyridinecarboxamide．C6H6N2O(122.12)．ニコチンアミドは，ナイアシンアミドともいう．ビタミンB複合体の一つで，ヒトの抗ペラグラ因子．ナイアシナミド，ナイアシンアミドということもある．ビタミンB群の一つであるナイアシンの活性を示す化合物の一つ．抗ペラグラ因子，ビタミンPPなどとよばれた．NAD，NADP合成の材料．動物，植物界にニコチン酸とともに広く分布しているが，ニコチン酸エステルの高圧，加熱アンモニア処理で得られる．白色の結晶．融点128～131 ℃．λmax 261 nm(ε 4.7，0.1 mol L－1 塩酸)．水，エタノール，グリセリンに易溶，ほかの有機溶媒に不溶．ニコチン酸アミドは二つの補酵素，NADおよびNADPの構成成分であり，生体中の酸化還元反応に関与している．森北出版「化学辞典（第2版）

• 生物学的性質

  欠乏症：ペラグラ(ヒト)，黒舌病(イヌ)．ニコチン酸も代用可．トリプトファンは1/60の作用　機能：ニコチン酸アデニンジヌクレオチドなどとして補酵素作用

• 用途

  薬理・医薬品研究用

• 生理機能

  ニコチンアミドは，ニコチン酸の酸アミドで、一般にはニコチンアミドnicotinamideとよばれている。ナイアシンアミドniacinamideともいう。分子式C6H6N2O、分子量122.13。ニコチン酸と同様に水溶性のビタミンB複合体の一つで、ヒトの抗ペラグラ因子である。イヌの黒舌(こくぜつ)病にも効果があり、微生物発育因子としても効果がある。生体内ではこのビタミンの補酵素型ニコチンアミドヌクレオチド、すなわちNADおよびNADPとして存在し、デヒドロゲナーゼの補酵素として多くの酸化還元反応に関与する。生理代謝的にはニコチン酸と同様にトリプトファンから生合成される。また、ニコチンアミダーゼによって加水分解され、生じたニコチン酸はNAD合成に再利用される。なお、ニコチン酸アミドは肝臓でメチル化されてN-メチルニコチン酸アミドとなり、尿中に排出される。［有馬暉勝・有馬太郎・竹内多美代］

• 作用と特徴

  ビタミンB群の一種で、別名として「ナイアシンアミド」または「ビタミンB3」とも呼ばれます。体内でさまざまな酸化還元反応を幅広くサポートする補酵素として働いています。皮膚や粘膜を正常に保つ作用や、血流をよくする作用があります。欠乏すると「ペラグラ（皮膚炎、胃腸障害、神経障害など）」の症状が起こることが知られています。
  ニコチン酸アミドは、肉体疲労時の滋養強壮・栄養補給ドリンク剤、にきび、肌荒れのケアを主目的としたビタミンB2B6主薬製剤などに幅広く配合されています。

• 化粧品の成分用途

  ヘアコンディショニング剤、皮膚コンディショニング剤

• 効能

  ニコチン酸補充薬

• 商品名

  ニコチン酸アミド (ゾンネボード製薬)

• 説明

  A white, crystalline powder. It is odorless or nearly so, and has a bitter taste. Its solutions are neutral to litmus. One g dissolves in about 1 mL of water, in about 1.5 mL of alcohol, and in about 10 mL of glycerin.

• 分布

  広く分布

• 化学的特性

  Niacinamide (Nicotinamide) is a white crystalline powder or forms colorless needle-like crystals.

• 使用

  Niacinamide is a nutrient and dietary supplement that is an available form of niacin. Nicotinic acid is pyridine beta-carboxylic acid and nicotinamide, which is another term for niacinamide, is the corresponding amide. It is a powder of good water solubility, having a solubility of 1 g in 1 ml of water. Unlike niacin, it has a bitter taste; the taste is masked in the encapsulated form. Used in fortification of cereals, snack foods, and powdered beverages. niacinamide is used as a skin stimulant and skin smoother. Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics.

• 定義

  ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

• 一般的な説明

  Vitamin B₃ was formerly called nicotinic acid; however, the term niacin is now preferred to avoid any confusion with the alkaloid, nicotine. Niacinamide, also known as nicotinamide, refers to the amide derivative of niacin that is equivalent in vitamin activity. Some texts use niacin to refer to nicotinic acid, niacinamide, and any derivatives with vitamin activity comparable to niacin. Furthermore, research and chemistry-based resources use the terms nicotinic acid and nicotinamide; whereas pharmacy resources use niacin and niacinamide.

• 空気と水の反応

  Water soluble.

• 反応プロフィール

  An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

• 臨床応用

  Niacin is used in the treatment of niacin deficiency, which is referred to as pellagra (from the Italian, pelle for “skin” and agra for “dry”). The major systems affected are the gastrointestinal tract (diarrhea, enteritis and stomatitis), the skin (dermatitis), and the CNS (generalized neurological deficits including dementia). Pellagra has become a rare condition in the United States and other countries that require or encourage enrichment of wheat flour or fortification of cereals with niacin. Because the nucleotide form can be synthesized in vivo from tryptophan, pellagra is most often seen in areas where the diet is deficient in both niacin and tryptophan. Typically, maize (corn)-based diets meet this criteria. Niacin deficiency can also result from diarrhea, cirrhosis, alcoholism, or Hartnup disease. It is interesting that niacin deficiency can also, rarely, result from vitamin B₆ deficiency (see Vitamin B₆ section). Niacin, but not niacinamide, is also one of the few vitamins that are useful in the treatment of diseases unrelated to deficiencies.

• 安全性プロファイル

  Nicotinamide is a safe and inexpensive compound with negligible side effects. It is well tolerated even in doses of 1g/day to 3g/day.There are no reports of teratogenicity with nicotinamide. Minor side effects include nausea, vomiting, headache, fatigue. It does not cause vasodilatory side effects like flushing, alteration in blood pressure, body temperature or pulse as seen with niacin.In topical formulation, it does not cause skin irritation, photosensitization in concentrations of 0.0001% to 4%.

• 職業ばく露

  Used as a dietary supplement and food additive.

• 代謝

  Nicotinamide is ingested in food as part of pyridine nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in plant and animal tissues. After the co?enzymes have separated, nicotinamide is absorbed almost completely in the small intestine. After absorption, nicotinamide is stored as NAD in the liver and excretion occurs via kidneys. Tryptophan is converted to nicotinamide through kynurenine?anthranilate pathway in the liver. Tryptophan can thus satisfy the requirement for dietary nicotinic acid.

• 純化方法

  Crystallise niacin from *benzene. It has solubility in g/ml: H2O (1), EtOH (0.7) and glycerol (0.1). [Methods in Enzymology 66 23 1980, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 83 1971, Beilstein 22 III/IV 389, 22/2 V 80.]

• 不和合性

  Combustible solid; dust may form explosive mixture with air. Amides are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

ニコチンアミド 上流と下流の製品情報

ニコチンアミド 生産企業

Global(1335)Suppliers

ニコチンアミド スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

98-92-0, ニコチンアミド キーワード