GLY-ARG-GLY-ASP-SER-PRO-LYS

GLY-ARG-GLY-ASP-SER-PRO-LYS 価格

GLY-ARG-GLY-ASP-SER-PRO-LYS 化学特性,用途語,生産方法

• 使用

  Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
  
  • as a blocking peptide to inhibit integrin-fibronectin binding
  • in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
  • for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
  • for the preparation of RGD.Flt23k.NR nanoparticles
  • to determine the involvement of RGD-integrin bonding in cell adhesion process

• 一般的な説明

  Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

• Biochem/physiol Actions

  Fibronectin analog that binds to integrins.

GLY-ARG-GLY-ASP-SER-PRO-LYS 生産企業

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