Lodoxamine tromethamine is a mast cell stabilizer that inhibits
Type I hypersensitivity responses by preventing antigen mediated
histamine release. Lodoxamine stabilizes mast cells by blocking
calcium influx into the cell upon antigen recognition, thereby
blocking histamine release. Lodoxamine has no intrinsic vasoconstrictor,
antihistaminic, cyclooxygenase inhibition or other anti-inflammatory
properties. Lodoxamine is used in people for management
of conjunctivitis associated with seasonal allergy and other
histamine mediated disorders. In veterinary medicine, lodoxamine
tromethamine has been used in horses and small animal patients
with presumed allergic conjunctivitis.
