2-ニトロアニソール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H350：発がんのおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

2-ニトロアニソール 価格

MSDS Information

• 2-Nitroanisole

2-ニトロアニソール 化学特性,用途語,生産方法

• 外観

  うすい黄色～黄褐色, 澄明の液体

• 溶解性

  水に不溶, エタノール, エーテルに易溶。エタノール、エーテルに可溶。水に不溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 化学的特性

  2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.

• 使用

  2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.

• 調製方法

  Methanolic sodium hydroxide is added slowly to a solution of 2- chloronitrobenzene in methanol at 70 ℃; the mixture is then heated gradually to 95 ℃ under pressure to complete the reaction. After dilution with water the product 2-Nitroanisole is separated as an oil, in 90 % yield, and methanol is recovered from the aqueous layer.

• 定義

  ChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.

• 一般的な説明

  2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.

• 危険性

  Questionable carcinogen.

• 安全性プロファイル

  Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.

• 職業ばく露

  A dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.

• 発がん性

  o-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

• 輸送方法

  UN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 純化方法

  Purify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]

• 不和合性

  A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures ＞110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide ＋ zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).

• 廃棄物の処理

  Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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