α-アマニチン
化学名:α-アマニチン
CAS番号.11030-71-0
英語名:α-Amanitin
CBNumberCB0944238
MFC39H53N9O14S
MW903.95502
MOL File11030-71-0.mol
别名
α-アマニチン
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| 毒性 | A drug derived from the highly poisonous fungus Amanita phalloides (death cap). Alpha-amanitin, a cyclic octapeptide, is toxic because of its affinity for RNA polymerase II in eukaryotic cells. Since this enzyme is responsible for mRNA synthesis in the cell, the compound is a potent and selective inhibitor of mRNA synthesis. It is effective at concentrations below 1 μg/mL, and its specific action has made it useful in experimental biology. It is often used with actinomycin D to block RNA synthesis. |