Iloprost

Iloprost 化学特性,用途語,生産方法

• 使用

  Treatment of pulmonary hypertension (prostacyclin analogue).

• 一般的な説明

  This more chemically and biologically stable derivativeof prostacyclin is available as a solution (10 μg/mL)for nasal inhalation (Ventavis by Actelion) via a preciselycalibrated inhalation device for the treatment of pulmonaryarterial hypertension (PAH). Patients inhale 6 to 8 puffs ofaerosolized iloprost every 2 to 3 hours to produce a directvasodilatory effect on pulmonary blood vessels, therebydecreasing vascular resistance. Side effects of coughing,flushing, headaches, and jaw pain have been most commonlyreported.

• 臨床応用

  Iloprost is administered as an inhalation solution of a prostacyclin analog for the treatment of NYHA class III and class IV PAH. The drug also can be administered as an IV infusion. It is stable at room temperature and to light, with a body half-life of 30 minutes. Iloprost has approximately 10 times greater potency than prostacyclin as a vasodilator of the pulmonary blood vessels; this greater potency of inhaled iloprost results from coating of the drug on the alveoli of the lungs.

• 副作用

  Studies have reported minor side effects, such as coughing, headaches, and jaw pain.

Iloprost 上流と下流の製品情報

Iloprost 生産企業

Global(58)Suppliers

73873-87-7, Iloprost キーワード