抗コレラトキシン抗体 ウサギ宿主抗体

抗コレラトキシン抗体 ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Anti-Cholera Toxin antibody produced in rabbit has been used in:
  
  • western blotting
  • quantitative ganglioside-dependent enzyme-linked immunoassay (ELISA)
  • double immunodiffusion
  
  

• 一般的な説明

  Cholera toxin, the pathogenic agent of cholera, is made of two subunits, A (27 kDa) and B (12 kDa) assembled with the stoichiometry AB5. The B-subunit binds to specific receptors, the monosialogangliosides GM1, located in the membrane of intestinal epithelial cells. The A1 fragment of the A-subunit is translocated through the membrane of the host cell, where it catalyses the ADP-ribosylation of the Gsa regulatory component of the adenylate cyclase complex. The resulting increased level of cyclic AMP promotes a wide variety of actions, including the secretion of chloride ions in the case of intestinal epithelial cells.

• Biochem/physiol Actions

  Cholera toxin (CT), a multifunctional protein plays a role in the immune system. It possesses immunomodulatory, adjuvant properties and also acts as an anti-inflammatory agent. Its immunomodulatory properties can be utilized to treat several autoimmune disorders. CT can serve as one of the best model of a multifunctional protein.

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