(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン 価格

(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい褐色, 結晶〜粉末

• 溶解性

  メタノールに溶ける。

• 用途

  ・糖タンパク細胞内転送阻害・ゴルジ体からのretrograde traffic・糖タンパクプロセシング部位の特定-アシル化とO-グルコシル化-抗原提示機序の解析・ウイルス増殖と合胞体形成の阻害

• 化学的特性

  White Powder

• 使用

  Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumour and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.

• 定義

  ChEBI: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.

• 一般的な説明

  Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583).

• 生物活性

  Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.

• 純化方法

  Brefeldin A was isolated from Penicillium brefeldianum and recrystallised from aqueous MeOH/EtOAc or MeOH. Its solubility in H2O is 0.6mg/mL, 10mg/mL in MeOH and 24.9mg/mL in EtOH. The O-acetate recrystallises from Et2O/pentane and has m 130-131o, [] D +17o (c 0.95, MeOH). [Sigg Helv Chim Acta 47 1401 1964, UV and IR: H.rri et al. Helv Chim Acta 46 1235 1963, total synthesis: Kitahara et al. Tetrahedron 3021 1979, X-ray : Weber et al. Helv Chim Acta 54 2763 1971, Beilstein 18 III/IV 1220.]

(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン 上流と下流の製品情報

(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン 生産企業

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(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン スペクトルデータ(¹HNMR)

20350-15-6, (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-デカヒドロ-1,13-ジヒドロキシ-6-メチル-4H-シクロペンタ[f]オキサシクロトリデシン-4-オン キーワード