1-セチルピリジニウム·クロリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H315：皮膚刺激

  H319：強い眼刺激

  H330：吸入すると生命に危険

  H335：呼吸器への刺激のおそれ

  H400：水生生物に強い毒性

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

1-セチルピリジニウム·クロリド 価格

MSDS Information

• Cetylpyridinium chloride

1-セチルピリジニウム·クロリド 化学特性,用途語,生産方法

• 外観

  白色～黄褐色、結晶性粉末～粉末

• 定義

  本品は、次の化学式で表される4級アンモニウム塩である。

• 用途

  口内殺菌消毒剤、咽頭炎、扁桃炎、口内炎の治療に用いる

• 化粧品の成分用途

  帯電防止剤、口腔ケア剤、殺菌剤、消臭剤

• 使用上の注意

  窒素封入

• 説明

  Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic activities. It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 μg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 μg/ml). Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%. Formulations containing cetylpyridinium have been used as antiseptic agents in the treatment of gingivitis and as antimicrobial agents in raw food processing.

• 化学的特性

  Cetylpyridinium chloride (CPC) is a white powder or crystals with a characteristic odor. It is slightly soapy to the touch.
  
  Cetylpyridinium chloride is a quaternary ammonium compound and is the active chemical in some human mouthwashes on the market. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. The antimicrobial activity is due to an interaction of basic cetylpyridinium ions with acidic molecules on bacteria, which subsequently inhibits bacterial metabolism by forming weak ionic compounds that interfere with bacterial respiration.

• 使用

  Antibacterial in cough lozenges and syrups; emulsifier.

• 定義

  ChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.

• 調製方法

  Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.

• 応用例（製薬）

  Cetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg.
  Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation,(1–3) although efficacy is variable owing to limited published data.

• 臨床応用

  1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
  The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.

• 安全性プロファイル

  Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.

• 安全性

  Cetylpyridinium chloride is used widely in mouthwashes as a bactericidal antiseptic. It is generally regarded as a relatively nontoxic material when used at a concentration of 0.05% w/v, although minor side effects such as mild burning sensations on the tongue have been reported.
  At higher concentrations, cetylpyridinium chloride may damage the mucous membranes in the mouth. It is harmful when ingested or inhaled. It can cause eye irritation, and is irritant to the respiratory system and the skin.
  LD₅₀ (rat, IP): 0.006 g/kg
  LD₅₀ (rat, IV): 0.03 g/kg
  LD₅₀ (rat, oral): 0.2 g/kg
  LD₅₀ (rat, SC): 0.25 g/kg
  LD₅₀ (mouse, IP): 0.01 g/kg
  LD₅₀ (mouse, oral): 0.108 g/kg
  LD₅₀ (rabbit, oral): 0.4 g/kg
  LD₅₀ (rabbit, IV): 0.036 g/kg

• 貯蔵

  Cetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.

• 不和合性

  Incompatible with strong oxidizing agents and bases. It is also incompatible with methylcellulose.
  Magnesium stearate suspensions in cetylpyridinium chloride have been shown to significantly reduce its antimicrobial activity. This is due to the absorption of cetylpyridinium chloride on magnesium stearate. The cetylpyridinium chloride ion also interacts with gelatin, resulting in reduced bioavailability.

• 規制状況(Regulatory Status)

  Included in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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