[1-ブチルアミノ-1-メチルエチル]ホスフィン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P362：汚染された衣類を脱ぎ、再使用す場合には洗濯をすること。

[1-ブチルアミノ-1-メチルエチル]ホスフィン酸 化学特性,用途語,生産方法

• 化学的特性

  Butafosfan is a white crystalline powder, very easily is dissolved in water. soluble in organic solvents such as ethanol, which should be purged with an inert gas. The solubility of butafosfan in ethanol is approximately 1 mg/ml. It has the effect that improves energy metabolism and strengthen immunologic function.

• 使用

  Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. When given with cyanocobalamin, butafosfan alters lipid metabolism, serving to decrease the prevalence of subclinical ketosis.

• 利点

  Butafosfan works by increasing the body's ability to metabolise glucose and other nutrients, as well as supporting the production of adenosine triphosphate, which is the main source of cellular energy. Cyanocobalamin, a form of vitamin B12, is essential for normal nerve function and red blood cell formation.

• 作用機序

  Butafosfan works by improving the body’s ability to metabolize glucose and other nutrients, as well as by supporting the production of ATP, which is the primary source of energy for cells. The association of Butafosfan and cyanocobalamin could favors the phosphorylation of molecules that intermediate metabolic pathways, such as a gluconeogenesis, glycolysis, and the Krebs cycle, improving the synthesis of the co-nutrients (ATP and ADP mainly) and consequently increasing blood glucose. However, it is still unclear if these results refer mainly to one of the nutrients, Butafosfan or cyanocobalamin[1].
  

• Toxicity evaluation

  The acute toxicity of butafosfan is very low. The oral LD50 in mice was approximately 16 000 mg/kg bw. After parenteral administrations, the following LD50 values were obtained in mice: approximately 21 000 mg/kg bw (subcutaneously), approximately 10 000 mg/kg bw (intravenously) and greater than 2500 mg/kg bw (intraperitoneally). Mice dosed orally or subcutaneously died within 3 and 2 days, respectively, while survivors had recovered by that time. The LD50 value in chicken (intramuscularly) was 9974 mg/kg bw. Observed toxic signs were excitation, cyanosis, sternal recumbency and diarrhoea.

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