InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem 化学特性,用途語,生産方法

• 一般的な説明

  A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC₅₀ = 200 nM from S. pombe; 0.3 μM for CK1δ) and ALK5 (IC₅₀ = 500 nM). A weak inhibitor of p38α MAP kinase (IC₅₀ = 12 μM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser³²² and Ser³²⁵) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC₅₀ = 2.5 μM for CK1).

• Biochem/physiol Actions

  Target IC50: 0.2 μM, 0.3 μM against CK1, CK1d, respectively

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem 生産企業

Global(2)Suppliers