rel-N-メチル-N-[(5R*)-7α*-(1-ピロリジニル)-1-オキサスピロ[4.5]デカン-8β*-イル]ベンゼンアセトアミド

rel-N-メチル-N-[(5R*)-7α*-(1-ピロリジニル)-1-オキサスピロ[4.5]デカン-8β*-イル]ベンゼンアセトアミド 価格

rel-N-メチル-N-[(5R*)-7α*-(1-ピロリジニル)-1-オキサスピロ[4.5]デカン-8β*-イル]ベンゼンアセトアミド 化学特性,用途語,生産方法

• 使用

  U-69593 is a selective κ-opioid receptor agonist. A safe opioid analgesic.

• 定義

  ChEBI: U69593 is a monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine. It has a role as a kappa-opioid receptor agonist, an anti-inflammatory agent and a diuretic. It is an oxaspiro compound, a N-alkylpyrrolidine, an organic heterobicyclic compound and a monocarboxylic acid amide.

• 生物学の機能

  U-69593 is a single enantiomer with very high selectivity for the kappa receptor in vitro (mu/kappa ratio = 484). It was radiolabelled by a catalytic exchange of tritium for the two aromatic chlorine substituents of the precursor. This ligand is commercially available and has been widely used as a radiolabel for the kappa receptor.
  in spinal cordslice preparations from the 9-16-day-old rat,U-69593 produced a na-loxone-reversible depression of spontaneous and electrically evoked activityin dorsal horn neurones.

• Biochem/physiol Actions

  U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

rel-N-メチル-N-[(5R*)-7α*-(1-ピロリジニル)-1-オキサスピロ[4.5]デカン-8β*-イル]ベンゼンアセトアミド 生産企業

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